Four Cases of Ketosis-Prone Diabetes Mellitus

Lee, Chan Woo; Ryu, Myeong Shin; Lee, Min Young; Lee, Mi Jin; Choi, Jong Su; Kang, Jun Goo; Kim, Chul Sik; Lee, Seong Jin; Hong, Eun Gyoung; Kim, Doo Man; Yu, Sung Hoon

doi:2010.11.4.342

J Korean Diabetes > Volume 11(4); 2010 > Article

Case Report

The Journal of Korean Diabetes 2010;11(4):342-348.
DOI: https://doi.org/10.4093/kcd.2010.11.4.342

Ketosis-prone 당뇨병 4예에 대한 임상적 고찰

이찬우, 유명신, 이민영, 이미진, 최종수, 강준구, 김철식, 이성진, 홍은경, 김두만, 유성훈

Four Cases of Ketosis-Prone Diabetes Mellitus

Chan Woo Lee, Myeong Shin Ryu, Min Young Lee, Mi Jin Lee, Jong Su Choi, Jun Goo Kang, Chul Sik Kim, Seong Jin Lee, Eun Gyoung Hong, Doo Man Kim, Sung Hoon Yu

Abstract

Ketosis-prone diabetes (KPD) is a widespread, heterogeneous syndrome characterized by diabetic ketoacidosis (DKA) or unprovoked ketosis without a precipitating cause that is not necessarily associated with the typical phenotype of autoimmune type 1 diabetes. The presence or absence of β-cell autoimmunity and β-cell functional reserve are important for pathophysiology, clinical course, and outcome. Recently, a few classifications were reported that were clinically and etiologically useful for predicting outcomes. The "A β" classification system of KPD has proven to be highly accurate and predictive of clinically important outcomes such as glycemic control and insulin dependence. We reviewed four Korean cases of KPD that manifested with DKA, along with a review of the related literature. (Korean Clinical Diabetes J 11:342-348, 2010)

Key Words: Classification, Diabetic ketoacidosis, Insulin therapy