Management of Patients with Nonalcoholic Fatty Liver Disease with Lifestyle Modification.

Lee,  Byung Wan

doi:2018.19.2.82

J Korean Diabetes > Volume 19(2); 2018 > Article

Focused Issue

The Journal of Korean Diabetes 2018;19(2):82-87.
DOI: https://doi.org/10.4093/jkd.2018.19.2.82 Published online July 9, 2018.

생활습관을 통한 지방간 관리 및 치료

이병완

Management of Patients with Nonalcoholic Fatty Liver Disease with Lifestyle Modification.

Byung Wan Lee

Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. bwanlee@yuhs.ac

Abstract

In the management and treatment of nonalcoholic fatty liver disease (NAFLD) ranging from hepatic steatosis (HS) to nonalcoholic steatohepatitis (NASH), the goals in patients without NASH or hepatic fibrosis are weight reduction through lifestyle modification such as nutritional and exercise intervention and control of associated metabolic morbidities including obesity, metabolic syndrome, and type 2 diabetes. Weight reduction of at least 3% to 5% could improve steatosis, and the characteristics of NASH histopathology with a dose-response curve between the degree of weight loss and improvement of histopathology. The patients with NAFLD could achieve weight reduction with hypocaloric diet with or without exercise, but not with exercise alone. Despite the absence of a weight loss effect of exercise alone, it may prevent or alleviate HS and associated metabolic parameters.

Key Words: Exercise, Hypocaloric diet, Lifestyle modification, Nonalcoholic fatty liver disease