J Korean Diabetes > Volume 11(4); 2010 > Article
The Journal of Korean Diabetes 2010;11(4):324-332.
DOI: https://doi.org/10.4093/kcd.2010.11.4.324   
지속형 인슐린과 인슐린 분비촉진제를 사용하는 제2형 당뇨병환자에서 공복 및 식후 C-peptide의 변화에 따른 혈당조절상태
이서희, 박소영, 김민강, 김은지, 유성훈, 강준구, 류옥현, 김철식, 이성진, 홍은경, 김두만, 유재명, 임성희, 최문기, 유형준
Glucose Control of the Patients with Type 2 Diabetes Using a Long Acting Insulin and Insulin Secretagogue According to Fasting and Postprandial C-peptide
Seo Hee Lee, So Young Park, Min Kang Kim, Eun Ji Kim, Sung Hoon Yu, Jun Goo Kang, Ohk Hyun Ryu, Chul Sik Kim, Seong Jin Lee, Eun Gyung Hong, Doo Man Kim, Jae Myung Yoo, Sung Hee Ihm, Moon Gi Choi, Hyung Joon Yoo
Abstract
Background
It has been noted that Korean type 2 diabetic patients have lower insulin secretory function than do diabetic patients of European descent. We conducted the present study to evaluate the relationship between glucose control and the difference between fasting and postprandial c-peptide in Korean type 2 diabetic patients. Methods: We evaluated fasting blood glucose level, fasting C-peptide level, A1C, lipid profiles, postprandial 2 hour blood glucose level, and postprandial 2 hour C-peptide level in 60 Korean type 2 diabetic patients (38 male, 22 female, age 51.9 ± 11.5 years old, duration of diabetes 9.6 ± 6.9 years, BMI 24.5 ± 2.9 kg/m2). We used fasting C-peptide, postprandial 2-hour C-peptide, and Δ C-peptide level to assess insulin secretory function and beta cell responsiveness. We divided patients into 3 groups according to Δ C-peptide level. The patients were treated using long acting insulin and insulin secretagogue (sulfonylurea, meglitinide). Three months later, we reevaluated fasting blood glucose, postprandial 2-hour glucose, and A1C according to Δ C-peptide level. Results: We observed decreases in Δ C-peptide according to duration of diabetes. However, there were no significant differences in the fasting blood glucose, post prandial 2 hour blood glucose, or A1C according to postprandial 2-hour C-peptide or Δ C-peptide. Conclusions: We did not observe significant improvements of blood glucose status according to the difference between fasting and postprandial C-peptide. (Korean Clinical Diabetes J 11:324-332, 2010)
Key Words: A1C, β-cell, C-peptide, Diabetes, Long acting insulin, Meglitinide, Sulfonylurea
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