A Case of Fulminant Type 1 Diabetes Mellitus after Hepatitis A Infection

Kwon, Ji Yeon; Roh, Mi Oh; Song, Min Soo; Jung, Chan Hee; Park, Hyeong Kyu; Kim, Yeo Ju; Mok, Ji Oh; Kim, Sang Jin; Kim, Chul Hee; Byun, Dong Won; Yu, Myung Hi; Suh, Kyo Il; Jung, Jung Hwa

doi:2009.10.2.118

J Korean Diabetes > Volume 10(2); 2009 > Article

Case Report

The Journal of Korean Diabetes 2009;10(2):118-122.
DOI: https://doi.org/10.4093/kcd.2009.10.2.118

급성 A형 간염 후 발생한 전격성 제1형 당뇨병 1예

권지연, 노미오, 송민수, 정찬희, 박형규, 김여주, 목지오, 김상진, 김철희, 변동원, 유명희, 서교일, 정정화

A Case of Fulminant Type 1 Diabetes Mellitus after Hepatitis A Infection

Ji Yeon Kwon, Mi Oh Roh, Min Soo Song, Chan Hee Jung, Hyeong Kyu Park, Yeo Ju Kim, Ji Oh Mok, Sang Jin Kim, Chul Hee Kim, Dong Won Byun, Myung Hi Yu, Kyo Il Suh, Jung Hwa Jung

Abstract

Fulminant type 1 diabetes mellitus is a novel subtype of type 1 diabetes, which is characterized by a remarkably abrupt onset, metabolic derangement such as diabetic ketoacidosis at diagnosis, low HbA1c level at onset and negative islet-related autoantibodies. The pathogenesis of this disease remains to be clarified, but the involvement of both genetic background and viruses have been suggested. We recently encountered a case of fulminant type 1 diabetes mellitus in 32-year-old male patient who was diagnosed with acute hepatitis A a month ago. Laboratory findings revealed high blood glucose level as well as evidence of diabetic ketoacidosis, but the HbA1c level was normal. The low level of plasma C-peptide indicated the loss of endogenous insulin secretion. This patient`s laboratory results met the criteria for the diagnosis of fulminant type 1 diabetes. We consider that this report can add to the body of evidence of a viral etiology of fulminant type 1 diabetes. Further study is needed to elucidate the exact pathogenesis. (Korean Clinical Diabetes J 10:118-122, 2009)

Key Words: Fulminant, Hepatitis A, Type 1 diabetes mellitus