Diabetes Monit 2002;3(4):326-337.
제2형 당뇨병에서 대혈관합병증 유무에 따른 경동맥 내막-중막 두께와 죽상동맥경화증 위험인자에 대한 연구
윤현대, 진명인, 유성수, 정덕수, 이지현, 손호상
Carotid Intima-Media Thickness (IMT) Measured by High Resolution B-mode Ultrasonography in Type 2 DM Patients with and without Macrovascular Complications and Their Relation with Atherosclerosis Risk Factors
Hyun Dae Yoon, Myoung In Jin, Sung Soo You, Duck Soo Chung, Ji Hyun Lee, Ho Sang Shon
Abstract
Background
Macrovascular complications such as cardiovascular and cerebrovascular accidents are major causes of diabetes mellitus-related morbidity and mortality. However, it is difficult to diagnose such macrovascular complications before clinical symptoms are evident. In many previous studies, the measurement of carotid intima-media thickness (IMT) has been a useful, non-invasive method to detect early atherosclerotic vascular changes. Methods: We measured carotid IMT by using high resolution B-mode ultrasonography in 103 type 2 diabetes patients with and without macrovascular complications. At the same time, we analyzed the patients` characteristics including height, weight, body mass index (BMI), blood pressure, duration of diabetes, and past history of hypertension and smoking. Laboratory parameters such as HbA1c, triglyceride, total cholesterol, LDL-cholesterol, HDL-cholesterol, apolipoprotein (A), apolipoprotein (B), Lp (a) and 24-hour urine microalbumin and protein were included in this study. Results: Age, blood pressure, glycosylated hemoglobin and diabetic nephropathy were significantly increased in type 2 diabetes patients with macrovascular complications. And type 2 diabetes patients with macrovascular complications showed significantly thicker maximal and mean carotid IMT than those without macrovascular complications. Maximal carotid IMT was an independent risk factor of macrovascular complication in type 2 diabetes patients, and was positively correlated with age, duration of diabetes, systolic blood pressure and LDL-cholesterol. Conclusion: The measurement of carotid IMT by using high resolution B-mode ultrasonography is a useful method for the early detection of macrovascular complications in type 2 diabetes patients.
Key Words: Type 2 Diabetes mellitus, Cardiovascular disease, Carotid atherosclerosis
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