Effect of Diabetes on Dementia and Its Preventive Strategies.

Kim,  Soo Kyung

doi:2012.13.3.140

J Korean Diabetes > Volume 13(3); 2012 > Article

Focused Issue

The Journal of Korean Diabetes 2012;13(3):140-144.
DOI: https://doi.org/10.4093/jkd.2012.13.3.140 Published online September 30, 2012.

당뇨병이 치매에 미치는 영향 및 예방법

김수경

Effect of Diabetes on Dementia and Its Preventive Strategies.

Soo Kyung Kim

Division of Endocrinology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Sungnam, Korea. imdrksk@chollian.net

Abstract

There is considerable evidence that type 2 diabetes and its related conditions increase the risk of dementia, although the associations are stronger for vascular dementia than Alzheimer's disease. In addition to cerebrovascular disease, type 2 diabetes mellitus and dementia share several other pathophysiologic features, including hyperinsulinemia, advanced glycation end-product, inflammation, and amyloid deposition. From a clinical perspective, evidence of a link between type 2 diabetes and dementia would suggest that currently available modalities to prevent or treat type 2 diabetes mellitus might be beneficial in preventing dementia, especially Alzheimer's disease. This review summarizes the existing evidence of a link between type 2 diabetes and dementia and the clinical trials that have investigated the effects of anti-diabetic modalities on cognitive outcomes in patients with type 2 diabetes mellitus or its precursor conditions.

Key Words: Alzheimer disease, Type 2 diabetes mellitus, Vascular dementia