Mechanism and Efficacy of New Anti-diabetic Medications.

Kwon,  Hyuk Sang

doi:2012.13.4.167

J Korean Diabetes > Volume 13(4); 2012 > Article

Opinion

The Journal of Korean Diabetes 2012;13(4):167-171.
DOI: https://doi.org/10.4093/jkd.2012.13.4.167 Published online December 27, 2012.

새로운 혈당강하제의 기전 및 효과

권혁상

Mechanism and Efficacy of New Anti-diabetic Medications.

Hyuk Sang Kwon

Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea. drkwon@catholic.ac.kr

Abstract

Previously proposed main pathogenic mechanisms for type 2 diabetes mellitus (T2DM) are increased hepatic glucose production, insulin resistance and insulin secretion defect. However, further mechanisms involved in the development of T2DM such as decreased incretin effect, increased glucose reabsorption and neurotransmitter dysfunction have been proposed recently. Based on these findings, various medications for glycemic control in T2DM are developing. In this review article, I will focus on the mechanisms and efficacies of up-coming new diabetes medications.

Key Words: Type 2 diabetes mellitus, Medication