Bone and Energy Metabolism.

Lee,  Sujin; Rhee,  Yumie

doi:2013.14.4.174

J Korean Diabetes > Volume 14(4); 2013 > Article

Focused Issue

The Journal of Korean Diabetes 2013;14(4):174-177.
DOI: https://doi.org/10.4093/jkd.2013.14.4.174 Published online December 24, 2013.

뼈와 에너지 대사

이수진, 이유미

Bone and Energy Metabolism.

Sujin Lee, Yumie Rhee

Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. yumie@yuhs.ac

Abstract

Bone remodeling requires a large amount of energy, and is regulated by various hormones. Leptin, produced by adipocytes, is a well-known regulator of energy balance and is also involved in controlling bone mass through interaction with the central nervous system. Serotonin, downstream of leptin, is also emerging as a candidate for controlling energy balance and bone metabolism. Currently, bone is also considered to be an endocrine regulator of energy metabolism. Osteocalcin, secreted from osteoblasts, is known to be a key regulator of glucose and fat metabolism. In this review, we describe a novel concept that asserts that there exists a biological link between bone and energy metabolism, and we summarize what is currently known about the relationship between bone and energy metabolism.

Key Words: Bone, Energy metabolism, Leptin, Serotonin, Neurotransmitter agents, Osteocalcin