Insulin Autoimmune Syndrome with Diabetic Ketoacidosis.

Jo,  Yeong Geol; Kim,  Young Il; Lee,  Su Jin; Kim,  Ki Won; Chun,  Sung Wan; Kim,  Yeo Joo; Kim,  Sang Jin

doi:2012.13.2.105

J Korean Diabetes > Volume 13(2); 2012 > Article

Case Report

The Journal of Korean Diabetes 2012;13(2):105-109.
DOI: https://doi.org/10.4093/jkd.2012.13.2.105 Published online June 30, 2012.

당뇨병케톤산증을 동반한 인슐린 자가면역 증후군 1예

조영걸, 김영일, 이수진, 김기원, 전성완, 김여주, 김상진

Insulin Autoimmune Syndrome with Diabetic Ketoacidosis.

Yeong Geol Jo, Young Il Kim, Su Jin Lee, Ki Won Kim, Sung Wan Chun, Yeo Joo Kim, Sang Jin Kim

Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan Hospital, Cheonan, Korea. yeojoo@schmc.ac.kr

Abstract

Insulin autoimmune syndrome is characterized by spontaneous hypoglycemia, elevated insulin level and a high level of insulin autoantibodies without previous insulin exposure. Among the clinical manifestations of insulin autoimmune syndrome, diabetic ketoacidosis is extremely rare. A 72-year-old diabetic woman was hospitalized with diabetic ketoacidosis. She suffered repeated fasting hypoglycemia after treatment of the diabetic ketoacidosis. Here we describe this case of insulin autoimmune syndrome manifested as diabetic ketoacidosis followed by recurrent hypoglycemia with a review of the relevant literature.

Key Words: Diabetic ketoacidosis, Hypoglycemia, Insulin autoantibody