A Case of Cushing`s Syndrome due to Adrenocortical Adenoma associated with Acute Pancreatitis and Diabetic Ketoacidosis

Han, Sang Woo; Park, Kang Seo; Jeon, Ho Seok; Seo, Dong Hyun; Lee, Jae Min; Sin, Sung Kyun; Hyun, Woo Jin; Park, Soon Hyun; Ku, Bon Jeong

Case Report

Diabetes Monit 2004;5(1):57-62.

당뇨병성 케톤산혈증과 급성 췌장염을 동반한 부신 선종에 의한 쿠싱증후군 1예

한상우, 박강서, 전호석, 서동현, 이재민, 신성균, 현우진, 박순현, 구본정

A Case of Cushing`s Syndrome due to Adrenocortical Adenoma associated with Acute Pancreatitis and Diabetic Ketoacidosis

Sang Woo Han, Kang Seo Park, Ho Seok Jeon, Dong Hyun Seo, Jae Min Lee, Sung Kyun Sin, Woo Jin Hyun, Soon Hyun Park, Bon Jeong Ku

Abstract

Cushing`s syndrome is produced by the hypersecretion of adrenal glucocorticoids and characreized by moon face, central obesity, disappearance of diurnal variation of plasma cortisol level and unsuppressibility of plasma cortisol level by low-dose dexametasone. Acute pancreatitis is produced by alcohol, gallstone, drugs, and rarely by hyperlipidemia. Hyperlipidemia and excessive corticosteroid by Cushing`s syndrome will cause acute pancreatitis. We report a rare case of Cushing`s syndrome due to adrenocortical adenoma associated with acute pancreatitis and diabetic ketoacidosis which was manifested by hypertension, central obesity, left adrenal mass and complicated by pancreatic pseudocyst on pancreatic head. Left adrenalectomy and external drainage of pancreatic pseudocyst were performed and hypertension improved after the operation.

Key Words: Cushing`s syndrome, Adrenocortical adenoma, Acute pancreatitis, Diabetic ketoacidosis