A Case of Severe Hyponatremia Induced by Duloxetine

Lee, Min Young; Park, Kyu Tae; Kang, Jun Goo; Ryu, Ohk Hyun; Kim, Chul Sik; Lee, Seong Jin; Kim, Hyeong Kyu; Hong, Eun Gyoung; Kim, Doo Man; Yu, Sung Hoon; Ihm, Sung Hee; Yu, Jea Myung; Choi, Moon Gi; Yoo, Hyung Joon

doi:2010.11.4.333

J Korean Diabetes > Volume 11(4); 2010 > Article

Case Report

The Journal of Korean Diabetes 2010;11(4):333-336.
DOI: https://doi.org/10.4093/kcd.2010.11.4.333

Duloxetine 투여 후에 발생한 중증 저나트륨혈증 1예

이민영, 박규태, 강준구, 류옥현, 김철식, 이성진, 김현규, 홍은경, 김두만, 유성훈, 임성희, 유재명, 최문기, 유형준

A Case of Severe Hyponatremia Induced by Duloxetine

Min Young Lee, Kyu Tae Park, Jun Goo Kang, Ohk Hyun Ryu, Chul Sik Kim, Seong Jin Lee, Hyeong Kyu Kim, Eun Gyoung Hong, Doo Man Kim, Sung Hoon Yu, Sung Hee Ihm, Jea Myung Yu, Moon Gi Choi, Hyung Joon Yoo

Abstract

Duloxetine is a balanced selective serotonin and norepinephrine reuptake inhibitor (SNRI) which was recently approved for treatment of painful diabetic peripheral neuropathy. Hyponatremia is a well-described adverse event of SSRIs and SNRI, although the exact mechanism is unknown. Hyponatremia related to these medications is believed to be caused by the syndrome of inappropriate antidiuretic hormone (SIADH) and is probably a rare event. We recently experienced severe hyponatremia in a 76-year-old diabetic patient who was taking duloxetine for painful diabetic peripheral neuropathy. We report a case of severe hyponatremia induced by duloxetine use and a review of the related literature. (Korean Clinical Diabetes J 11:333-336, 2010)

Key Words: Diabetic neuropathy, Duloxetine, Hyponatremia, SIADH